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The Brisbane AF Clinic is dedicated to furthering knowledge and treatments of AF and education about AF.  Dr Karen Phillips is involved in active research with regular presentation of clinical abstracts at cardiac scientific meetings and continued publication in peer- reviewed medical journals.  Dr Karen Phillips has been a Principal Investigator for several international clinical trials on leading edge AF treatments.


Cardialen MultiPulse Therapy (MPT) for AF

The purpose of this study was to assess the clinical safety and feasibility of MultiPulse Therapy (MPT) electrical stimulation waveform sequence in terminating paroxysmal and persistent atrial fibrillation in a patient group undergoing catheter ablation treatment for AF.


OPTION ‘Comparison of Anticoagulation With Left Atrial Appendage Closure After AF Ablation’

The primary objective of this study was to determine if left atrial appendage closure with the WATCHMAN FLX Device is a reasonable alternative to oral anticoagulation following percutaneous catheter ablation for high risk patients with atrial fibrillation.


AMPLATZER™ Amulet™ LAA Occluder Trial (Amulet IDE)

The purpose of this study was to evaluate the Amulet™ device for safety and efficacy by comparing its performance to the commercially available WATCHMAN® left atrial appendage closure device in patients with non-valvular atrial fibrillation. Patients who are eligible for the trial will be randomized to receive either the Amulet device or the WATCHMAN device and will be followed for 5 years after device implant.


WASP (Watchman Asia Pacific Real World Outcomes) Registry

This was an observational, prospective, non-randomized, multicenter study with the following objectives: (1) to compile real-world clinical outcomes data for WATCHMAN Left Atrial Appendage Closure Technology in patients who are implanted with the WATCHMAN device in a commercial clinical setting and (2) to collect health care usage data that may be needed for reimbursement of WATCHMAN technology in certain countries.


ZERO-AF  “Clinical Evaluation of the Blazer Open-Irrigated Ablation Catheter for the Treatment of Paroxysmal Atrial Fibrillation”

The purpose of this study was to establish the safety and effectiveness of the Blazer Open-Irrigated radiofrequency ablation catheter for the treatment of drug refractory, recurrent, symptomatic, paroxysmal atrial fibrillation.


Coherex WaveCrest® Left Atrial Appendage Occlusion Study 

The purpose of this study was a “first in man” assessment of the WaveCrest device which is designed to be placed in the opening of the left atrial appendage (LAA) to prevent stroke in patients with atrial fibrillation.



Impact of anticoagulation strategy after left atrial appendage occlusion in patients requiring direct current cardioversion.

Journal of Cardiovascular Electrophysiology (January 2021)

Cost-effectiveness of combined catheter ablation and left atrial appendage closure for symptomatic atrial fibrillation in patients with high stroke and bleeding risk

American Heart Journal (August 2020)

Combining left atrial appendage closure and catheter ablation for atrial fibrillation: 2-year outcomes from a multinational registry.

Europace Journal (February 2020)


Left atrial appendage closure with WATCHMAN in Asian patients: 2 year outcomes from the WASP registry.

International Journal of Cardiology Heart & Vasculature (April 2019)

Combined atrial fibrillation ablation and left atrial appendage closure: long-term follow-up from a large multicentre registry.

Europace Journal (March 2018)

Dealing With the Left Atrial Appendage for Stroke Prevention: Devices and Decision-Making.

Heart Lung Circulation (August 2017)

Combining Watchman left atrial appendage closure and catheter ablation for atrial fibrillation: multicentre registry results of feasibility and safety during implant and 30 days follow-up.

Europace Journal (June 2017)

Long Term Outcomes from Catheter Ablation of Very Longstanding Persistent Atrial Fibrillation.

International Journal of Cardiology (November 2016)

Pursuing Early Catheter Ablation to Treat Trial Fibrillation in the Congestive Heart Failure Population: Significance of the AATAC Trial Results.

Journal of Thoracic Disease (August 2016)

Combined catheter ablation for atrial fibrillation and Watchman® left atrial appendage occlusion procedures: Five-year experience.

Journal of Arrhythmia (April 2016)

Left Atrial Appendage Closure: Mechanical Approaches to Stroke Prevention (Saw, Kar, Price editors)

Springer (April 2016)

Left atrial catheter ablation subsequent to Watchman® left atrial appendage device implantation: a single centre experience.

Europace Journal (May 2015)

Double transseptal puncture adjacent to multiple Amplatzer atrial septal occluders: case report.

Heart,Lung and Circulation (April 2015)

Observations Of Electrical Coupling Index Using The Contact™ System During Pulmonary Vein Electrical Isolation Procedures.

JAFIB (June 2014)

Role of Inflammation in Initiation and Perpetuation of Atrial Fibrillation: A Systematic Review of the Published Data.

JAFIB (October 2013)

Combined Catheter Ablation for Atrial Fibrillation and Watchman® Left Atrial Appendage Occlusion Procedures: A Single Centre Experience.

JAFIB (October 2012)

Anatomical analysis of the left atrial appendage using segmented, three-dimensional cardiac CT: a comparison of patients with paroxysmal and persistent forms of atrial fibrillation.

Journal of Interventional Cardiac Electrophysiology (August 2012)

Esophageal Dilatation Post - Gastric Banding and Catheter Ablation for Atrial Fibrillation: A Case Report.

JAFIB (June 2009)

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